Eastoff
But it was a beginning.
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http://www.theverge.com/2014/3/27/5553044/first-functional-eukaryotic-chromosome
Eukaryotic chromosomes belong to eukaryotes — organisms such as animals, plants, and yeast whose cells contain a membrane-bound nucleus. Although scientists have previously been able to construct viral DNA and bacterial DNA, the synthesis of a eukaryotic chromosome had not been achieved. So, when the scientists decided to construct a chromosome from scratch, they knew they had to plan it out carefully. "We didn't make a carbon copy of an existing chromosome," says Jef Boeke, a molecular biologist at New York University and co-author of the study, "but an extensively modified version designed on a computer, using a set of principles that were predicted to make happy, healthy yeast."
