Orion Bailey
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hmm okay. Be nice if people stepped up then when others claim bothsiderism is an issue…
Ive been told i cant have it both ways on so many things…
OT Coronavirus: America in chaos, News and Updates. One million Americans dead and counting
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hmm okay. Be nice if people stepped up then when others claim bothsiderism is an issue…
Ive been told i cant have it both ways on so many things…
THE HCP
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I'll say it again. It all depends on what you use social media for. For the nut jobs that use it for politics/religion and other bullshit...... that's on them. My family uses facebook to stay in touch and share pics and updates on our kids. Thats the extent. So when people say how BAD facebook is.... I just don't see it. We use Instagram for photography. Everybody in my family loves to take pics and share with friends and family. If those out there are using it for that other shit, that's on them. I use twitter for sports updates and recruiting for my daughter. I just don't see the BAD in social media.
THE HCP
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This is what should and will be happening soon everywhere in my opinion.
Hoopguru
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If a person can manage the use and still function in society that's great! I would never advocate in getting rid of either.
I remember saying to myself I would never buy anything over the net, now I see it as no big deal.
Back in mid 80's I was provided a Think Pad lap top for e-mail and intranet. I got a e-mail from the VP's secretary saying my computer may be infected. I didnt know if I should used rubber gloves or throw the damn think out the window.
I spend a lot a time on here, and have other things to do, so Im self governing. lol
Phatguysrule
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I've been told the same. I tell them I agree that one side its more threatening to democracy than the other, however, if both sides want it this way we're doing ourselves a huge disservice if we pretend one side or the other actually wants change.
riverman
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I dumped facebook long long ago and never had twitter...my wife has a facebook acct to share photos and uses it for that but you're talking to a guy who got his first cell phone 4 years ago....miss that land line! I judge twitter after watching the country run by it for 4 years straight.....to me...some dangerous shit...all the other social stuff I think you can do with a phone and an email acct....old school habits die hard! This place is the only real place I use socially on the net. The msg function on my Iphone covers a lot of ground for necessary stuff. As someone who's never had twitter but seen how badly it's been used and promoted by people in leadership positions or with massive followings...I think that's something you can easily just remove from your life bro....I know you'll miss your selfies! I keep in touch with family all over the world with just a cell phone or laptop and msg function and skype or zoom.
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BigGameDamian
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I think that's a duopoly or an oligopoly not a pair of monopolies. Unless you think they aren't competing for the same customers, which is arguable either way.
barfo
tlongII
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https://katu.com/news/local/osu-stu...-V0dR0d_h1WnRY2ItSqg7HH0ec20-6g2GG4dNX3seiVKU
OSU study: Compounds in hemp block COVID-19 from entering human cells
CORVALLIS, Ore. – Compounds found in hemp "show the ability to prevent the virus that causes COVID-19 from entering human cells," Oregon State University says.
New OSU research on hemp and COVID-19 was published Tuesday in the Journal of Natural Products.
Richard van Breemen, a researcher with Oregon State’s Global Hemp Innovation Center in the College of Pharmacy and Linus Pauling Institute, led the study.
According to OSU:
Hemp, known scientifically as Cannabis sativa, is a source of fiber, food and animal feed, and multiple hemp extracts and compounds are added to cosmetics, body lotions, dietary supplements and food, van Breemen said.Van Breemen and collaborators, including scientists at Oregon Health & Science University, found that a pair of cannabinoid acids bind to the SARS-CoV-2 spike protein, blocking a critical step in the process the virus uses to infect people.The compounds are cannabigerolic acid, or CBGA, and cannabidiolic acid, CBDA, and the spike protein is the same drug target used in COVID-19 vaccines and antibody therapy. A drug target is any molecule critical to the process a disease follows, meaning its disruption can thwart infection or disease progression.
“These cannabinoid acids are abundant in hemp and in many hemp extracts,” van Breemen said. “They are not controlled substances like THC, the psychoactive ingredient in marijuana, and have a good safety profile in humans. And our research showed the hemp compounds were equally effective against variants of SARS-CoV-2, including variant B.1.1.7, which was first detected in the United Kingdom, and variant B.1.351, first detected in South Africa.”
OSU said those two variants are also known as alpha and beta.
According to OSU:
Characterized by crown-like protrusions on its outer surface, SARS-CoV-2 features RNA strands that encode its four main structural proteins – spike, envelope, membrane and nucleocapsid – as well as 16 nonstructural proteins and several “accessory” proteins, van Breemen said.
“Any part of the infection and replication cycle is a potential target for antiviral intervention, and the connection of the spike protein’s receptor binding domain to the human cell surface receptor ACE2 is a critical step in that cycle,” he said. “That means cell entry inhibitors, like the acids from hemp, could be used to prevent SARS-CoV-2 infection and also to shorten infections by preventing virus particles from infecting human cells. They bind to the spike proteins so those proteins can’t bind to the ACE2 enzyme, which is abundant on the outer membrane of endothelial cells in the lungs and other organs.”
Van Breem said "using compounds that block virus-receptor interaction has been helpful for patients with other viral infections" including HIV-1 and hepatitis.
According to OSU:
Van Breemen, Ruth Muchiro of the College of Pharmacy and Linus Pauling Institute and five scientists from OHSU identified the two cannabinoid acids via a mass spectrometry-based screening technique invented in van Breemen’s laboratory. Van Breemen’s team screened a range of botanicals used as dietary supplements including red clover, wild yam, hops and three species of licorice.An earlier paper in the Journal of the American Society for Mass Spectrometry described tailoring the novel method, affinity selection mass spectrometry, to finding drugs that would target the SARS-CoV-2 spike protein.In the later research, lab tests showed that cannabigerolic acid and cannabidiolic acid prevented infection of human epithelial cells by the coronavirus spike protein and prevented entry of SARS-CoV-2 into cells.
“These compounds can be taken orally and have a long history of safe use in humans,” van Breemen said. “They have the potential to prevent as well as treat infection by SARS-CoV-2. CBDA and CBGA are produced by the hemp plant as precursors to CBD and CBG, which are familiar to many consumers. However, they are different from the acids and are not contained in hemp products.”
According to OSU:
Van Breemen explains that affinity selection mass spectrometery, which he abbreviates to AS-MS, involves incubating a drug target like the SARS-CoV-2 spike protein with a mixture of possible ligands – things that might bind to it – such as a botanical extract, in this case hemp extract.The ligand-receptor complexes are then filtered from the non-binding molecules using one of several methods.
“We identified several cannabinoid ligands and ranked them by affinity to the spike protein,” van Breemen said. “The two cannabinoids with the highest affinities for the spike protein were CBDA and CGBA, and they were confirmed to block infection.
“One of the primary concerns in the pandemic is the spread of variants, of which there are many, and B.1.1.7 and B.1.351 are among the most widespread and concerning,” he added. “These variants are well known for evading antibodies against early lineage SARS-CoV-2, which is obviously concerning given that current vaccination strategies rely on the early lineage spike protein as an antigen. Our data show CBDA and CBGA are effective against the two variants we looked at, and we hope that trend will extend to other existing and future variants.”
Van Breemen noted that "resistant variants could still arise amid widespread use of cannabinoids but that the combination of vaccination and CBDA/CBGA treatment should make for a much more challenging environment for SARS-CoV-2."
“Our earlier research reported on the discovery of another compound, one from licorice, that binds to the spike protein too,” he said. “However, we did not test that compound, licochalcone A, for activity against the live virus yet. We need new funding for that.”
OSU said Timothy Bates, Jules Weinstein, Hans Leier, Scotland Farley and Fikadu Tafesse of OHSU also contributed to the cannabinoid study.
OSU study: Compounds in hemp block COVID-19 from entering human cells
CORVALLIS, Ore. – Compounds found in hemp "show the ability to prevent the virus that causes COVID-19 from entering human cells," Oregon State University says.
New OSU research on hemp and COVID-19 was published Tuesday in the Journal of Natural Products.
Richard van Breemen, a researcher with Oregon State’s Global Hemp Innovation Center in the College of Pharmacy and Linus Pauling Institute, led the study.
According to OSU:
Hemp, known scientifically as Cannabis sativa, is a source of fiber, food and animal feed, and multiple hemp extracts and compounds are added to cosmetics, body lotions, dietary supplements and food, van Breemen said.Van Breemen and collaborators, including scientists at Oregon Health & Science University, found that a pair of cannabinoid acids bind to the SARS-CoV-2 spike protein, blocking a critical step in the process the virus uses to infect people.The compounds are cannabigerolic acid, or CBGA, and cannabidiolic acid, CBDA, and the spike protein is the same drug target used in COVID-19 vaccines and antibody therapy. A drug target is any molecule critical to the process a disease follows, meaning its disruption can thwart infection or disease progression.
“These cannabinoid acids are abundant in hemp and in many hemp extracts,” van Breemen said. “They are not controlled substances like THC, the psychoactive ingredient in marijuana, and have a good safety profile in humans. And our research showed the hemp compounds were equally effective against variants of SARS-CoV-2, including variant B.1.1.7, which was first detected in the United Kingdom, and variant B.1.351, first detected in South Africa.”
OSU said those two variants are also known as alpha and beta.
According to OSU:
Characterized by crown-like protrusions on its outer surface, SARS-CoV-2 features RNA strands that encode its four main structural proteins – spike, envelope, membrane and nucleocapsid – as well as 16 nonstructural proteins and several “accessory” proteins, van Breemen said.
“Any part of the infection and replication cycle is a potential target for antiviral intervention, and the connection of the spike protein’s receptor binding domain to the human cell surface receptor ACE2 is a critical step in that cycle,” he said. “That means cell entry inhibitors, like the acids from hemp, could be used to prevent SARS-CoV-2 infection and also to shorten infections by preventing virus particles from infecting human cells. They bind to the spike proteins so those proteins can’t bind to the ACE2 enzyme, which is abundant on the outer membrane of endothelial cells in the lungs and other organs.”
Van Breem said "using compounds that block virus-receptor interaction has been helpful for patients with other viral infections" including HIV-1 and hepatitis.
According to OSU:
Van Breemen, Ruth Muchiro of the College of Pharmacy and Linus Pauling Institute and five scientists from OHSU identified the two cannabinoid acids via a mass spectrometry-based screening technique invented in van Breemen’s laboratory. Van Breemen’s team screened a range of botanicals used as dietary supplements including red clover, wild yam, hops and three species of licorice.An earlier paper in the Journal of the American Society for Mass Spectrometry described tailoring the novel method, affinity selection mass spectrometry, to finding drugs that would target the SARS-CoV-2 spike protein.In the later research, lab tests showed that cannabigerolic acid and cannabidiolic acid prevented infection of human epithelial cells by the coronavirus spike protein and prevented entry of SARS-CoV-2 into cells.
“These compounds can be taken orally and have a long history of safe use in humans,” van Breemen said. “They have the potential to prevent as well as treat infection by SARS-CoV-2. CBDA and CBGA are produced by the hemp plant as precursors to CBD and CBG, which are familiar to many consumers. However, they are different from the acids and are not contained in hemp products.”
According to OSU:
Van Breemen explains that affinity selection mass spectrometery, which he abbreviates to AS-MS, involves incubating a drug target like the SARS-CoV-2 spike protein with a mixture of possible ligands – things that might bind to it – such as a botanical extract, in this case hemp extract.The ligand-receptor complexes are then filtered from the non-binding molecules using one of several methods.
“We identified several cannabinoid ligands and ranked them by affinity to the spike protein,” van Breemen said. “The two cannabinoids with the highest affinities for the spike protein were CBDA and CGBA, and they were confirmed to block infection.
“One of the primary concerns in the pandemic is the spread of variants, of which there are many, and B.1.1.7 and B.1.351 are among the most widespread and concerning,” he added. “These variants are well known for evading antibodies against early lineage SARS-CoV-2, which is obviously concerning given that current vaccination strategies rely on the early lineage spike protein as an antigen. Our data show CBDA and CBGA are effective against the two variants we looked at, and we hope that trend will extend to other existing and future variants.”
Van Breemen noted that "resistant variants could still arise amid widespread use of cannabinoids but that the combination of vaccination and CBDA/CBGA treatment should make for a much more challenging environment for SARS-CoV-2."
“Our earlier research reported on the discovery of another compound, one from licorice, that binds to the spike protein too,” he said. “However, we did not test that compound, licochalcone A, for activity against the live virus yet. We need new funding for that.”
OSU said Timothy Bates, Jules Weinstein, Hans Leier, Scotland Farley and Fikadu Tafesse of OHSU also contributed to the cannabinoid study.
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Some things legitimately can be both-sided, some can't.
For example, if you want to talk about politicians accepting cash bribes, there are examples on both sides.
But if you want to talk about how many babies S2 posters eat, you really don't hold a baby-tallow-candle to me.
barfo
BigGameDamian
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Road Ratt
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COVID-19: The idea of mild Omicron ‘needs to be eradicated,’ emergency physician stresses.
https://www.msn.com/en-us/health/me...cated-emergency-physician-stresses/vi-AASFV7z
https://www.msn.com/en-us/health/me...cated-emergency-physician-stresses/vi-AASFV7z
Phatguysrule
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Right. Biden has done so much to solve... Nothing.
Look, he's not as terrible as Trump. No question. He's still been a disaster for any progressive policy.
He has time. I hope he proves me wrong.
THE HCP
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Ya I don't follow any political accounts on twitter. So all the bad/controversial tweets and blasts, I actually only see on here, not my feed.
Phatguysrule
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I don't disagree, that's why I voted for Biden. The Republicans are so over the top bad that it's actually dangerous to the country to allow many of them to win.
Simply saying that pretending the DNC is good is incredibly dangerous. They are right wing in most other countries. Biden in particular is very regressive, and always has been.
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BigGameDamian
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https://abcnews.go.com/amp/Health/wireStory/omicron-headed-rapid-drop-us-britain-82206037
Omicron may be headed for a rapid drop in US and Britain
Scientists are seeing signals that COVID-19′s alarming omicron wave may have peaked in Britain and is about to do the same in the U.S., at which point cases may start dropping off dramatically
Omicron may be headed for a rapid drop in US and Britain
Scientists are seeing signals that COVID-19′s alarming omicron wave may have peaked in Britain and is about to do the same in the U.S., at which point cases may start dropping off dramatically
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And what comes after omicron? pi! And everyone likes pi. Baseball, hot dogs, covid pi and Chevrolet. Happy days are here again!
barfo
BigGameDamian
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We’ll see. Last wave? We’ve heard that before.
riverman
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more like shaved heads all around, matching jump suits and barcode tats so you can get your daily ration of green mystery glop and have no sex and go by an ID number like THX1138 ..all public service jobs will be staffed with robots
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Anthony Fauci calls Sen. Roger Marshall ‘a moron’ during tense committee hearing on COVID-19 (yahoo.com)
A frustrated Anthony Fauci appeared to call U.S. Sen. Roger Marshall, R-Kan., a "moron" during a tense exchange Tuesday, as Fauci fielded questions from lawmakers on his work on the country's COVID-19 response.
A frustrated Anthony Fauci appeared to call U.S. Sen. Roger Marshall, R-Kan., a "moron" during a tense exchange Tuesday, as Fauci fielded questions from lawmakers on his work on the country's COVID-19 response.
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May he be blessed for what he means and what he says ~ 
jonnyboy
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The sycophantic admiration you see directed at Fauci is really disturbing. The guy was a complete fuck up before covid ever even happened. His handling of HIV and AIDS was disastrous and probably criminal. The guy is a total scumbag.
Phatguysrule
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Bullshit.
Road Ratt
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Scumbag is what it takes to reach the highest levels of congress these days. At this point, we should just rename America "The Empire" and have all of our presidents titles begin with Darth.
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Road Ratt
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Lanny
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Incorrect. He's giving thousands of pharmacies test kits and administration funds for the non insured. There will be 500 Million test kits in all free to everybody who wants one. You can also get them by mail and can request them either on line or by telephone.
Lanny
Original Season Ticket Holder "Mr. Big Shot"
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". . . You see the mob takes the Fifth. If you’re innocent why are you taking the Fifth Amendment?” - Donald Trump