Science Miracle Drug or the next HCQ?

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HailBlazers

HailBlazers

RipCity
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Anti-parasite drugs sweep Nobel prize in medicine 2015

Each year, Merck gives away some 270 million treatments of the drug.
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“People are dying at unacceptable and untold rates, “I am a lung and ICU specialist, and all I do right now is take care of COVID-19 patients dying of breathlessness in ICUs. By the time they get to the ICU, it is nearly impossible to save most patients. They simply cannot breathe.”

Epidemiologic analyses on COVID-19 and Ivermectin

AP News: No evidence Ivermectin is a miracle drug against COVID-19

CLAIM: The antiparasitic drug ivermectin “has a miraculous effectiveness that obliterates” the transmission of COVID-19 and will prevent people from getting sick.

AP’S ASSESSMENT: False. There’s no evidence ivermectin has been proven a safe or effective treatment against COVID-19.

THE FACTS: During a Senate hearing Tuesday, a group of doctors touted alternative COVID-19 treatments, including ivermectin and the anti-malaria medication hydroxychloroquine. Medical experts have cautioned against using either of those drugs to treat COVID-19. Studies have shown that hydroxychloroquine has no benefit against the coronavirus and can have serious side effects. No evidence has been shown to prove that ivermectin works against COVID-19.

Dr. Amesh Adalja, an infectious disease expert at Johns Hopkins University, said most of the research around ivermectin at the moment is made up of anecdotes and studies that are not the gold standard in terms of how to use ivermectin.

“We need to get much more data before we can say this is a definitive treatment,” he said. “We would like to see more data before I recommend it to my patients.”
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@SlyPokerDoc

Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19 : American Journal of Therapeutics

Meta-analyses based on 18 randomized controlled treatment trials of ivermectin in COVID-19 have found large, statistically significant reductions in mortality, time to clinical recovery, and time to viral clearance. Furthermore, results from numerous controlled prophylaxis trials report significantly reduced risks of contracting COVID-19 with the regular use of ivermectin. Finally, the many examples of ivermectin distribution campaigns leading to rapid population-wide decreases in morbidity and mortality indicate that an oral agent effective in all phases of COVID-19 has been identified.

To date, the efficacy of ivermectin in COVID-19 has been supported by the following:
  1. Since 2012, multiple in vitro studies have demonstrated that Ivermectin inhibits the replication of many viruses, including influenza, Zika, Dengue, and others.9–17

  2. Ivermectin inhibits SARS-CoV-2 replication and binding to host tissue through several observed and proposed mechanisms.18

  3. Ivermectin has potent anti-inflammatory properties with in vitro data demonstrating profound inhibition of both cytokine production and transcription of nuclear factor-κB (NF-κB), the most potent mediator of inflammation.37–39

  4. Ivermectin significantly diminishes viral load and protects against organ damage in multiple animal models when infected with SARS-CoV-2 or similar coronaviruses.31,32

  5. Ivermectin prevents transmission and development of COVID-19 disease in those exposed to infected patients.40–45

  6. Ivermectin hastens recovery and prevents deterioration in patients with mild to moderate disease treated early after symptoms.45,49–52,61,62

  7. Ivermectin hastens recovery and avoidance of ICU admission and death in hospitalized patients.45,51,53,63–66

  8. Ivermectin reduces mortality in critically ill patients with COVID-19.45,53,63

  9. Ivermectin leads to temporally associated reductions in case fatality rates in regions after ivermectin distribution campaigns.48

  10. The safety, availability, and cost of ivermectin are nearly unparalleled given its low incidence of important drug interactions along with only mild and rare side effects observed in almost 40 years of use and billions of doses administered.75

  11. The World Health Organization has long included ivermectin on its “List of Essential Medicines.”
 
Sweet. Too bad 1 in 169 people will have access to this when it is made available.
 
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