Science Naturally occurring molecule rivals Ozempic in weight loss, sidesteps side effects

[Phatguysrule]

Naturally occurring molecule rivals Ozempic in weight loss, sidesteps side effects

The 12-amino-acid BRP peptide (spheres are atoms and sticks are bonds) suppresses appetite and reduces weight gain in mice and pigs without causing nausea or food aversion.

A Stanford Medicine study taps artificial intelligence to find a naturally occurring molecule called a peptide that suppressed appetite and led to weight loss in mice and pigs.

Read More

 

[riverman]

Best weight loss program is simple...control your diet. Move your body and stop eating junk food, fried foods and sugar. Stop drinking soda pop and beer...get used to fruit and veggies and cut carbs. When you crave a snack, have a glass of water instead. Zero side effects and you control what goes in your body. Take control of your body.

 

[Strenuus]

Best weight loss program is simple...control your diet. Move your body and stop eating junk food, fried foods and sugar. Stop drinking soda pop and beer...get used to fruit and veggies and cut carbs. When you crave a snack, have a glass of water instead. Zero side effects and you control what goes in your body. Take control of your body.

Easier said than done when people have a history to contend with too. So I dare say it's not "simple" in these more convenient times.

 

[JfizzleBlazer]

Everyone is different with what works for them. Some people have medical issues and medications they take that make them gain weight too.

With that said, I know someone that took ozempic. They said they started bleeding through vomiting and diarrhea. They don't care as long as they are losing weight.

Society sucks.

 

[UncleCliffy'sDaddy]

Easier said than done when people have a history to contend with too. So I dare say it's not "simple" in these more convenient times.

Yes and no. I have fought a weight problem my entire life. I tried all the various diets, starved myself, over exercised, etc, etc, etc. When I was first dealing with cardiac issues my electrophysiologist told me in no uncertain terms, that it wasn't so much how much I ate, but what I ate. That if I ate the "correct" way, I could pretty much eat as much as I wanted. Over time I made the necessary changes and saw almost immediate results. I cut down (if not eliminated completely) processed sugars (and processed foods in general), virtually all carbs that weren't "complex" and laid off the beer. I also got much more consistent with my walking. I lost 10-12 pounds within 2 weeks. The weight loss slowed down after that but still continued at a slower pace. It is hard to stick to a (somewhat) limited diet and consistent exercise but it pays off. Anytime I "slip" for more than a day or two I notice a difference in how I feel.....and sugar goes straight to my gut at the speed of light. What I'm saying is, doing the "right" things is a process with no end. It takes discipline, along with the occasional rewards. All I know is that once upon a time I weighed as much as 265 lbs, and when my doctor finally got through to me I was at 228 lbs and holding. Today I'm bouncing 185-190 with hopes it will go lower. But if you remember nothing else, processed sugar is the enemy! Processed sugar is poison and should be used sparingly, if at all.

 

[Strenuus]

Yes and no. I have fought a weight problem my entire life. I tried all the various diets, starved myself, over exercised, etc, etc, etc. When I was first dealing with cardiac issues my electrophysiologist told me in no uncertain terms, that it wasn't so much how much I ate, but what I ate. That if I ate the "correct" way, I could pretty much eat as much as I wanted. Over time I made the necessary changes and saw almost immediate results. I cut down (if not eliminated completely) processed sugars (and processed foods in general), virtually all carbs that weren't "complex" and laid off the beer. I also got much more consistent with my walking. I lost 10-12 pounds within 2 weeks. The weight loss slowed down after that but still continued at a slower pace. It is hard to stick to a (somewhat) limited diet and consistent exercise but it pays off. Anytime I "slip" for more than a day or two I notice a difference in how I feel.....and sugar goes straight to my gut at the speed of light. What I'm saying is, doing the "right" things is a process with no end. It takes discipline, along with the occasional rewards. All I know is that once upon a time I weighed as much as 265 lbs, and when my doctor finally got through to me I was at 228 lbs and holding. Today I'm bouncing 185-190 with hopes it will go lower. But if you remember nothing else, processed sugar is the enemy! Processed sugar is poison and should be used sparingly, if at all.

I cut out sugar. It was only hard the first 2 weeks.

Cutting out caffeine and soda was so easy.

It's the meals that are the toughest for me. I do exercise now. But the food part is the hardest for a lot of people.

 

[Everything Beagle]

Best weight loss program is simple...control your diet. Move your body and stop eating junk food, fried foods and sugar. Stop drinking soda pop and beer...get used to fruit and veggies and cut carbs. When you crave a snack, have a glass of water instead. Zero side effects and you control what goes in your body. Take control of your body.

Fucking laughing out loud. It was simple for you. Well done.

 

[Phatguysrule]

Best weight loss program is simple...control your diet. Move your body and stop eating junk food, fried foods and sugar. Stop drinking soda pop and beer...get used to fruit and veggies and cut carbs. When you crave a snack, have a glass of water instead. Zero side effects and you control what goes in your body. Take control of your body.

These help you do that without suffering the mental side effects that depriving your natural tendencies can lead to (and so often results in resuming unhealthy behaviors).

There is a lot of evidence that there are genetic drivers which are incredibly hard to overcome. People who don't have significant weight problems and even those who are able to lose weight and keep it off tend to have different genetic markers than those who are more resistant. This is becoming more clear the more data we have.

These solutions remove those drivers which associate food with rewards. Thereby significantly reducing or even eliminating the mental component.

This allows people to eat for subsistence only, and make the healthy decisions you have identified.

 

[UncleCliffy'sDaddy]

I cut out sugar. It was only hard the first 2 weeks.

Cutting out caffeine and soda was so easy.

It's the meals that are the toughest for me. I do exercise now. But the food part is the hardest for a lot of people.

Especially when we live in one of the better foodie towns in the country.......

 

[MickZagger]

Move people. Just move.

Sedentary lifestyle is usually the major culprit.

 

[Phatguysrule]

Move people. Just move.

Sedentary lifestyle is usually the major culprit.

You can't out work the kitchen. The math simply doesn't pencil out.

 

[MickZagger]

You can't out work the kitchen. The math simply doesn't pencil out.

That’s a major part of it too. But if you never burn calories your body usually gets that way in the first place

 

[Everything Beagle]

These help you do that without suffering the mental side effects that depriving your natural tendencies can lead to (and so often results in resuming unhealthy behaviors).

There is a lot of evidence that there are genetic drivers which are incredibly hard to overcome. People who don't have significant weight problems and even those who are able to lose weight and keep it off tend to have different genetic markers than those who are more resistant. This is becoming more clear the more data we have.

These solutions remove those drivers which associate food with rewards. Thereby significantly reducing or even eliminating the mental component.

This allows people to eat for subsistence only, and make the healthy decisions you have identified.

I’ve successfully lost 70+ pounds twice. Both times it was hell. I don’t really form habits easily, which means I had to micromanage everything I put in my body, track it down to the minute and individual calorie. It worked, for about a year each time. I did not feel better. I did not feel more capable or sharper mentally or morally at ease. I felt hungry. I felt bored. And when the routine had to change (usually when work moved me to a different building that didn’t serve the same food) everything fell apart and in another year I’d be back up higher than when I’d started. I have given up on losing weight.

But here’s the funny thing: my numbers are straight down the middle. My doctor hated me for years because he wanted to get me in a lapband so bad but couldn’t justify it with numbers… he literally fired me as a patient when I refused to do it.

Yeah my knees suck, but they always have; sure I get winded faster than my peers but if they had to carry a 200lb guy on their back for three flights of stairs, they’d be more winded than me. In the end, it doesn’t even matter. I’ll produce a slightly greasier smoke in the cremation oven than a thin person. And then it’ll be over.

 

[Phatguysrule]

That’s a major part of it too. But if you never burn calories your body usually gets that way in the first place

Agreed. You definitely need to be active to be healthy.

 

[Phatguysrule]

I’ve successfully lost 70+ pounds twice. Both times it was hell. I don’t really form habits easily, which means I had to micromanage everything I put in my body, track it down to the minute and individual calorie. It worked, for about a year each time. I did not feel better. I did not feel more capable or sharper mentally or morally at ease. I felt hungry. I felt bored. And when the routine had to change (usually when work moved me to a different building that didn’t serve the same food) everything fell apart and in another year I’d be back up higher than when I’d started. I have given up on losing weight.

But here’s the funny thing: my numbers are straight down the middle. My doctor hated me for years because he wanted to get me in a lapband so bad but couldn’t justify it with numbers… he literally fired me as a patient when I refused to do it.

Yeah my knees suck, but they always have; sure I get winded faster than my peers but if they had to carry a 200lb guy on their back for three flights of stairs, they’d be more winded than me. In the end, it doesn’t even matter. I’ll produce a slightly greasier smoke in the cremation oven than a thin person. And then it’ll be over.

I've done it as well. There were good moments, but overall life definitely wasn't better.

It sounds like GLP-1 is what bodies that are prone to overeating are trying to compensate for.

These treatments replace GLP-1 so you don't miss the feeling of joy or satiety you get from overeating. So you can more easily just eat as much as needed.

Problem is, ozempic is patented, scarce (EXPENSIVE), and can have crazy side effects.

My understanding is that this natural alternative would be far more accessible and seems like there is much lower risk of serious side effects.

 

[Everything Beagle]

I've done it as well. There were good moments, but overall life definitely wasn't better.

It sounds like GLP-1 is what bodies that are prone to overeating are trying to compensate for.

These treatments replace GLP-1 so you don't miss the feeling of joy or satiety you get from overeating. So you can more easily just eat as much as needed.

Problem is, ozempic is patented, scarce (EXPENSIVE). and can have crazy side effects.

I believe this natural alternative would be for more accessible and seems like there is much lower risk of serious side effects.

That'd be neat if it actually happens.

 

[barfo]

This is interesting, but still quite distant from being available for use - at least assuming that the FDA still requires any checks on safety or efficacy once Elon gets done gutting it.

barfo

 

[riverman]

If it works for you, great. I hope it gets you the results you want. For me, it was eliminating things that got me to a healthy weight and moving, not being sedentary. I just gave up ice cream and went from pre diabetic blood sugar levels to great numbers with my last test...I love ice cream and over indulged in it...don't eat it any more because it spikes my blood sugar. Wife did the same. It worked in both our cases. Boring, but diet and exercise are really effective. I felt immediately better every time I adjusted or eliminated something in my diet, not worse so for me, it's a no brainer to start there. My brother in law is going blind from diabetes right now and he's my age. I sure didn't smarten up early about it, took a heart failure for me to wake up about a lot of stuff.

 

[riverman]

Fucking laughing out loud. It was simple for you. Well done.

It was a heart attack that turned me around a decade ago, guess that's simple but if it works for anyone else who needs encouragement, that's all I can offer.
The hard one for me was tobacco. I went from 220 to 168 and have stayed 168 for the last year and change. I'm real happy about it. A lot of my friends struggle with it. One did the stomach stapling thing and it helped him. Whatever you have to do, I wish you luck.

 

[UncleCliffy'sDaddy]

Agreed. You definitely need to be active to be healthy.

What works for me is having a dog (or two). They need to be exercised. It took me awhile to force myself to do it and be consistent about it because I am generally lazy. But eventually it became a habit and now I actually look forward to getting out early every morning with my little friend for an hour. Rain (the dogs, wife and I all have good rain gear) or shine, we're out there. It has actually become a form of therapy; quiet time to sort through whatever is driving that day's "bus". And I feel the best I have in a long time, mentally and physically. I also try to get in a walk all by myself later in the day. Walking may not cover all the major muscle groups but it is an easy and free way to lose weight as long as you stay consistent......

Edit: And after smoking at least a pack a day for most of 40 years quitting was one of the easiest things I have ever done. All it took was a book by Allan Carr, called The Easy Way To Stop Smoking. Simple behavior modification that rewired my brain. An absolutely incredible book for anyone who is serious about getting off nicotine.

 

[Phatguysrule]

If it works for you, great. I hope it gets you the results you want. For me, it was eliminating things that got me to a healthy weight and moving, not being sedentary. I just gave up ice cream and went from pre diabetic blood sugar levels to great numbers with my last test...I love ice cream and over indulged in it...don't eat it any more because it spikes my blood sugar. Wife did the same. It worked in both our cases. Boring, but diet and exercise are really effective. I felt immediately better every time I adjusted or eliminated something in my diet, not worse so for me, it's a no brainer to start there. My brother in law is going blind from diabetes right now and he's my age. I sure didn't smarten up early about it, took a heart failure for me to wake up about a lot of stuff.

I'm not sure any of this will work. It's just interesting technology. Ozempic has been transformational for millions of people. If you read the reviews of people who use it and don't have terrible side effects they are blown away at how much their lives have improved.

And if a more natural alternative can be made readily available at low cost and helps as many or more I just think that would be great.

It's also interesting that this discovery happened because it shows some exciting applications for AI.

 

[crandc]

It's not as simple as will power and exercise. Many poor people live in food deserts. People working multiple jobs, or rotating shifts, have trouble cooking and eating on schedule. Cheap food is crappy food. Often cities don't have sidewalks and poor people are less likely to have access to parks, pools, etc.
Covid hurt. The joke about Covid 19. Stuck at home with little to do but cook and bake and wondering if we were all going to die. I am still trying to take off my Covid 19. Also when people get older losing weight is harder.

 

[Everything Beagle]

It's also interesting that this discovery happened because it shows some exciting applications for AI.

This is not the same AI as the other AI that also isn’t AI.

 

[Phatguysrule]

AlphaFold 3 predicts the structure and interactions of all of life’s molecules

Update November 11, 2024: As of November 2024, we have released AlphaFold 3 model code and weights for academic use to help advance research. Learn more about AlphaFold tools.

Original post: Inside every plant, animal and human cell are billions of molecular machines. They’re made up of proteins, DNA and other molecules, but no single piece works on its own. Only by seeing how they interact together, across millions of types of combinations, can we start to truly understand life’s processes.

Read More

 

[Everything Beagle]

Get me high enough and I can outperform any pattern-matching AI John Henry style.

 

[Everything Beagle]

We’re going to figure out in the next 50 years that there actually isn’t any grand secret to life, that life isn’t just abundant but mathematically inevitable. The amino acids yearn to become more complex. The universe exists to express itself over and over at every energy level, fractally. And yet, for all our complexity, we are nothing more than a universe of proteins living their lives inside a saltwater spaceship. Our brains are the greatest achievement yet of a nearly infinite committee of mitochondria voting with chemical secretions.

 

[Shaboid]

We’re going to figure out in the next 50 years that there actually isn’t any grand secret to life, that life isn’t just abundant but mathematically inevitable. The amino acids yearn to become more complex. The universe exists to express itself over and over at every energy level, fractally. And yet, for all our complexity, we are nothing more than a universe of proteins living their lives inside a saltwater spaceship. Our brains are the greatest achievement yet of a nearly infinite committee of mitochondria voting with chemical secretions.

 

[Everything Beagle]

View attachment 72205

I knew I should have ended my post with “Eat Arby’s”

 

[Hoopguru]

I try and live by food is fuel, and it's important to know what good and appropriate for your daily routine or extra routine. My Moto used to be eat to run, and run to eat.

 

[SlyPokerDog]