OT: Lauren & JRue Holiday

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crandc said:
I am willing to be corrected if anyone posts a link to peer reviewed studies on efficacy of cannabis/coconut oil for brain tumors. Serious.
Click to expand...

https://www.researchgate.net/public...er_Cells_due_to_Induction_of_Oxidative_Stress

Induction of Apoptosis by the Medium-Chain Length Fatty Acid Lauric Acid in Colon Cancer Cells due to Induction of Oxidative Stress

Abstract
Background: Fatty acids are classified as short-chain (SCFA), medium-chain (MCFA) or long-chain and hold promise as adjunctive chemotherapeutic agents for the treatment of colorectal cancer. The antineoplastic potential of MCFA remains underexplored; accordingly, we compared the MCFA lauric acid (C12:0) to the SCFA butyrate (C4:0) in terms of their capacity to induce apoptosis, modify glutathione (GSH) levels, generate reactive oxygen species (ROS), and modify phases of the cell cycle in Caco-2 and IEC-6 intestinal cell lines. Methods: Caco-2 and IEC-6 cells were treated with lauric acid, butyrate, or vehicle controls. Apoptosis, ROS, and cell cycle analysis were determined by flow cytometry. GSH availability was assessed by enzymology. Results: Lauric acid induced apoptosis in Caco-2 (p < 0.05) and IEC-6 cells (p < 0.05) compared to butyrate. In Caco-2 cells, lauric acid reduced GSH availability and generated ROS compared to butyrate (p < 0.05). Lauric acid reduced Caco-2 and IEC-6 cells in G0/G1and arrested cells in the S and G2/M phases. Lauric acid induced apoptosis in IEC-6 cells compared to butyrate (p < 0.05). Butyrate protected IEC-6 cells from ROS-induced damage, whereas lauric acid induced high levels of ROS compared to butyrate.

Conclusion: Compared to butyrate, lauric acid displayed preferential antineoplastic properties, including induction of apoptosis in a CRC cell line.




Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death.
 
bodyman5000 and 1 said:
The question I want answered is this. How much would you trust a doctor that told you your wife could wait to have a brain tumor removed?

I'd want that thing out pronto.
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It really depends on the tumor and the prognosis. There are a lot of different types of tumors that grow at different rates. The reason to postpone the surgery is for the benefit of both the mother and the unborn child. My niece had a brain tumor removed in her late 20s, in between the births of her two daughters. She's now 55 and has had no further complications. Her doctor would not recommend postponing the surgery if he did not think it in his patient's best interest.

BNM
 
Boob-No-More said:
It really depends on the tumor and the prognosis. There are a lot of different types of tumors that grow at different rates. The reason to postpone the surgery is for the benefit of both the mother and the unborn child. My niece had a brain tumor removed in her late 20s, in between the births of her two daughters. She's now 55 and has had no further complications. Her doctor would not recommend postponing the surgery if he did not think it in his patient's best interest.

BNM
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I believe that but I hope they got more opinions about it.
 
Denny Crane said:
https://www.researchgate.net/public...er_Cells_due_to_Induction_of_Oxidative_Stress

Induction of Apoptosis by the Medium-Chain Length Fatty Acid Lauric Acid in Colon Cancer Cells due to Induction of Oxidative Stress

Abstract
Background: Fatty acids are classified as short-chain (SCFA), medium-chain (MCFA) or long-chain and hold promise as adjunctive chemotherapeutic agents for the treatment of colorectal cancer. The antineoplastic potential of MCFA remains underexplored; accordingly, we compared the MCFA lauric acid (C12:0) to the SCFA butyrate (C4:0) in terms of their capacity to induce apoptosis, modify glutathione (GSH) levels, generate reactive oxygen species (ROS), and modify phases of the cell cycle in Caco-2 and IEC-6 intestinal cell lines. Methods: Caco-2 and IEC-6 cells were treated with lauric acid, butyrate, or vehicle controls. Apoptosis, ROS, and cell cycle analysis were determined by flow cytometry. GSH availability was assessed by enzymology. Results: Lauric acid induced apoptosis in Caco-2 (p < 0.05) and IEC-6 cells (p < 0.05) compared to butyrate. In Caco-2 cells, lauric acid reduced GSH availability and generated ROS compared to butyrate (p < 0.05). Lauric acid reduced Caco-2 and IEC-6 cells in G0/G1and arrested cells in the S and G2/M phases. Lauric acid induced apoptosis in IEC-6 cells compared to butyrate (p < 0.05). Butyrate protected IEC-6 cells from ROS-induced damage, whereas lauric acid induced high levels of ROS compared to butyrate.

Conclusion: Compared to butyrate, lauric acid displayed preferential antineoplastic properties, including induction of apoptosis in a CRC cell line.




Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death.
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Is there a translation of this into English?
 
No one here knows what the best treatment for this particular patient is. We all hope her doctor does. Best of health to her. :cheers:
 
BBert said:
Is there a translation of this into English?
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Yes. Coconut oil kills cancer cells. Coconut oil contains MCT (medium chain triglycerides/fatty acids). The CRCs are the cancer cells. The apoptosis of those cells is their "programmed cell death"

It was experimentally observed. They put the cells in petri dishes and added various things, then analyzed the result. This is the peer reviewed paper that crandc asked for.

I certainly wouldn't recommend someone forgo treatment and take coconut oil instead. It doesn't hurt to take it along with the treatment though.

There's a lot to be said for treating disease with diet. This is becoming more clear as more research is being done.

@Further
 
The last thing I'd ever do is pretend like I know anything about curing a brain tumor but I know medical marijuana can ease a lot of discomfort.. I'm sure they have the best doctors available to make this decision...I just hope she survives and they are successful with the treatment
 
Denny Crane said:
Yes. Coconut oil kills cancer cells. Coconut oil contains MCT (medium chain triglycerides/fatty acids). The CRCs are the cancer cells. The apoptosis of those cells is their "programmed cell death"

It was experimentally observed. They put the cells in petri dishes and added various things, then analyzed the result. This is the peer reviewed paper that crandc asked for.

I certainly wouldn't recommend someone forgo treatment and take coconut oil instead. It doesn't hurt to take it along with the treatment though.

There's a lot to be said for treating disease with diet. This is becoming more clear as more research is being done.

@Further
Click to expand...
Yes, I think you said it fairly plainly. However, I would mention that in vitro (in the petri dish) a gigantic list of things drive apoptosis, whereas in vivo (in living organisms like mice or humans) that list dwindles greatly at high enough dosages, at least without causing other death-inducing side affects.

A quick search of in vivo coconut oil studies - I didn't find any successful cancer inhibiting studies, but I did find some interesting results about virgin coconut oil being used in mice to combat depression and stress. The cause was unknown but MCT's were one of the leading theories.

I wouldn't use it to combat cancer personally, but there could be some health benefits. There does seem to be a fair amount of evidence that coconut oil does help in the absorption of many vitamins and some nutrients. So much so, that it is included now in some hospital infant formulas to aid in malnutrition and malnourishment. Actually, MCT's are used in many hospital feeding formulas now for all ages.





As far as Lauren and Drue, I hope they come through this healthy with their family in tact. Such a tough thing for anyone to go through.






EDIT
I certainly wouldn't recommend someone forgo treatment and take coconut oil instead. It doesn't hurt to take it along with the treatment though.
Click to expand...
We actually don't if it would hurt to take alongside other treatments. I suspect you are correct, but there have been many instances of drugs and foods adversely meshing with certain cancer therapeutics.
 
Last edited:
Further said:
Yes, I think you said it fairly plainly. However, I would mention that in vitro (in the petri dish) a gigantic list of things drive apoptosis, whereas in vivo (in living organisms like mice or humans) that list dwindles greatly at high enough dosages, at least without causing other death-inducing side affects.

A quick search of in vivo coconut oil studies - I didn't find any successful cancer inhibiting studies, but I did find some interesting results about virgin coconut oil being used in mice to combat depression and stress. The cause was unknown but MCT's were one of the leading theories.

I wouldn't use it to combat cancer personally, but there could be some health benefits. There does seem to be a fair amount of evidence that coconut oil does help in the absorption of many vitamins and some nutrients. So much so, that it is included now in some hospital infant formulas to aid in malnutrition and malnourishment. Actually, MCT's are used in many hospital feeding formulas now for all ages.





As far as Lauren and Drue, I hope they come through this healthy with their family in tact. Suck a tough thing for anyone to go through.






EDIT

We actually don't if it would hurt to take alongside other treatments. I suspect you are correct, but there have been many instances of drugs and foods adversely meshing with certain cancer therapeutics.
Click to expand...

I agree. You can test things in mice but you never really know until humans are tested. Same for petri dishes.

Even then, human trials are subject to confounding and are really expensive to run.
 
The study Denny cited showed cells - not a live animal. Something that works in a Petri dish is intriguing but hardly a cure. And "enhances the quality of life" is important, but something that enhances the quality of life (which is not a cure, just makes you feel better) for breast cancer may not work for brain tumors. I agree that restrictions on research involving marijuana are stupid and unscientific.

But I also state that none of us are Ms. Holiday's doctor, none of us know exactly what her condition is, and she is best off working with those who do. The uninvolved can just wish her well.
 
crandc said:
But I also state that none of us are Ms. Holiday's doctor, none of us know exactly what her condition is, and she is best off working with those who do. The uninvolved can just wish her well.
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Why do you take this so personal? It's like you take these suggestions as a personal attack. You think Ms. Holiday is gonna read this stupid message board?
 
crandc said:
The study Denny cited showed cells - not a live animal. Something that works in a Petri dish is intriguing but hardly a cure. And "enhances the quality of life" is important, but something that enhances the quality of life (which is not a cure, just makes you feel better) for breast cancer may not work for brain tumors. I agree that restrictions on research involving marijuana are stupid and unscientific.

But I also state that none of us are Ms. Holiday's doctor, none of us know exactly what her condition is, and she is best off working with those who do. The uninvolved can just wish her well.
Click to expand...

You asked for a peer reviewed study. You got it.

You acted like there's nothing to it. There's something to it.

There are 1600+ peer reviewed and published studies about coconut oil:

http://www.ncbi.nlm.nih.gov/pubmed/?term=coconut+oil



I'm a big fan of the ketogenic diet. There is a lot of claims about it being a cure for cancer. For example:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215472/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871217/

But I'm more inclined to believe you are less likely to get cancer in the first place on the diet rather than it being a cure once you have cancer not on the diet.
 
Denny Crane said:
There are 1600+ peer reviewed and published studies about coconut oil:
Click to expand...
Far more if you add in related searches like "medium chain fatty acids,” “medium chain triglycerides,” “lauric acid,” “capric acid,” “caprylic acid,”. There has been a lot of research on these topics, with some interesting results, but not too many extraordinary results. In aggregate, not too impressive, but still likely an overall positive for people to take.
 
Further said:
Far more if you add in related searches like "medium chain fatty acids,” “medium chain triglycerides,” “lauric acid,” “capric acid,” “caprylic acid,”. There has been a lot of research on these topics, with some interesting results, but not too many extraordinary results. In aggregate, not too impressive, but still likely an overall positive for people to take.
Click to expand...

First hit.

http://www.ncbi.nlm.nih.gov/pubmed/7759747

If you're dying, then "potential" is something to grasp for?
 
For a FlatEarther who thinks that climate change scientists are just saying it to make money, you sure are good at citing scientists when they're on your side.
 
jlprk said:
For a FlatEarther who thinks that climate change scientists are just saying it to make money, you sure are good at citing scientists when they're on your side.
Click to expand...

I think the state of the 60,000+ studies related to low carb dieting alone, on the NIH site, is a pretty good snapshot of science in general. Poorly executed studies with all sorts of confounding factors, and cherry picked citations to support the scientist's bias.

As with AGW, the science isn't settled.
 
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