Dame was at the top decile in the NBA as the handler in pick and roll plays. The only player on POR that was in the top decile as a roller in the same games was DJJ - a mobile athletic freak that went hard to the rim. 2nd best was Kanter (4th decile) who is a big body that can set good picks. He is not very agile (west/east) but he can go hard to the rim and at least has good hands. This tells you how great Dame is at initiating the pick and roll despite the facts that he did not have great teammates rolling for him last year. IIRC, before Nurk went down in 2018 - the 2 of them were the top pick and roll duo in the league despite Nurk's well know sub-optimal finishes around the rim.
Now imagine that there is a new roll man option in Ben Simmons, a bigger athletic freak than DJJ with much more agility than Kanter and the ability to find people in transition if he the opposing team manages to collapse on him. I honestly think this would be a really scary combination to stop for the rest of the league. In a standard pick and roll you have one of the best handlers in the league in Dame, getting picks from a big body that is an athletic freak that can go hard to the rim (and scores very efficiently there). In addition, both the ball handler and the roll man are excellent and finding others if the defense manages to contain them with good shooters all around.
In addition, because of Dame's ridiculous range, the Blazers can now run 2 sets of north/south pick and roll starting from the half court if they really want, Dame and Simmons and if there is a need (Simmons love to attack the rim from the handle with the ball in his hands, a great place to put it for him as the roll man) - a secondary one with Simmons as the handler (which he is capable of doing) and Nurk. At the same time, somehow the defense now manages to collapse back on both of them - you know who can move without the ball and get it for a 3P attempt, Dame... - scary shit.