Pertinent excerpts from Sagan's "The Demon-Haunted World":
"Have I ever heard a skeptic wax superior and contemptuous? Certainly. I've even sometimes heard, to my retrospective dismay, that unpleasant tone in my own voice. There are human imperfections on both sides of this issue. Even when it's applied sensitively, scientific skepticism may come across as arrogant, dogmatic, heartless and dismissive of the feelings and deeply held beliefs of others. And, it must be said, some scientists and dedicated skeptics apply this tool as a blunt instrument, with little finesse. Sometimes it looks as if the skeptical conclusion came first, that contentions were dismissed before, not after, the evidence was examined. All of us cherish our beliefs. They are, to a degree, self-defining. When someone comes along who challenges our belief system as insufficiently well-based - or who, like Socrates, merely asks embarrassing questions that we haven't thought of, or demonstrates that we've swept key underlying assumptions under the rug - it becomes much more than a search for knowledge. It feels like a personal assault.
...
In the way that skepticism is sometimes applied to issues of public concern, there is a tendency to belittle, to condescend, to ignore the fact that, deluded or not, supporters of superstition and pseudoscience are human beings with real feelings, who, like the skeptics, are trying to figure out how the world works and what our role in it might be. Their motives are in many cases consonant with science. If their culture has not given them all the tools they need to pursue this great quest, let us temper our criticism with kindness. None of us comes fully equipped.
Clearly there are limits to the uses of skepticism. There is some cost-benefit analysis which must be applied, and if the comfort, consolation and hope delivered by mysticism and superstition is high, and the dangers of belief comparatively low, should we not keep our misgivings to ourselves? But the issue is tricky. Imagine that you enter a big-city taxicab and the moment you get settled in the driver begins a harangue about the supposed iniquities and inferiorities of another ethnic group. Is your best course to keep quiet, bearing in mind that silence conveys assent? Or is it your moral responsibility to argue with him, to express outrage, even to leave the cab - because you know that every silent assent will encourage him next time, and every vigorous dissent will cause him next time to think twice? Likewise, if we offer too much silent assent about mysticism and superstition - even when it seems to be doing a little good - we abet a general climate in which skepticism is considered impolite, science tiresome, and rigorous thinking somehow stuffy and inappropriate. Figuring out a prudent balance takes wisdom."