Define "do well."
Are you talking about simply scoring points? Yes, I'm sure you could drop any number of HOF centers into the NBA today and they'd score points, but that style of offense just doesn't exist much anymore. Dumping the ball into the post and everyone standing around while the center backs their man down. That's what Edey does. His team dumps the ball into him and he backs his man down. Marang said that Edey was in the 100th percentile in the number of post ups this year in the NCAA. That's all he does. That's all he CAN do. He doesn't pick and pop. He doesn't pick and roll. He picks and posts. Ayton is a MUCH more versatile scoring big man. The league wants bigs who can shoot the three, spread the floor, but can also attack the rim.
The entire league is swinging towards super mobile centers who can defend the perimeter. Guys who can't do that tend to get played off the court during the playoffs. Offense is irrelevant at the 5 if they can't shoot. Just look at KAT. He went from 1 3PA per game during his rookie season up to almost 8 attempts per game in 19-20. The entire league is hedging towards three point shooting because that's what the math tells them is the most efficient way to win games. So going to get guys who can't shoot and can't defend the perimeter would be problematic. It might work during the regular season, but we have seen Gobert go from DPOY to unplayable in multiple playoffs because he can't score on the perimeter and he gets hunted on defense. So could you drop some HOF centers into this league and watch them feast in the middle? Sure. I'm sure they'd have great regular seasons. But in a playoff series against a team that plays 5 out like OKC, who shoots 30+ three pointers per game, that center is going to become a liability if they can't defend.