Sure, but if you're using that as the model, it goes to what I was saying--Simmons would be playing the LeBron role in the offense (as James was/is a big, gifted passer who has been a questionable shooter--better and much, much more willing than Simmons, but still not exactly an ideal floor spacer) with Lillard more similar to Irving as someone who can play the ball-dominant role but had to transition into more of an off-ball role for LeBron/Simmons. The difference there was that James is a living legend and in the argument for greatest ever, while Irving was just some punk kid. Irving really had no clout to challenge the set-up (but it obviously bothered him and he ultimately broke up the relationship).
I'm not saying the same thing would happen with Lillard, but no matter how smart Simmons, Lillard and whomever the coach was, Lillard couldn't be the constant central hub. Sometimes, sure...but mostly Simmons would have to be, because that's where the majority of his talents lie. So I'm not saying it's binary, that Lillard never gets to touch the ball except to shoot--I'm saying Lillard would have to give up a lot of ball-handling he currently does and he probably would have to give up being the central hub of the offense. And unlike the James/Irving pairing, Lillard wouldn't be clearly the inferior player--so how happy would he be with that? Maybe it doesn't matter--as long as Lillard isn't mutinous about it (and I wouldn't expect him to be), they could probably survive him not being thrilled.