OT Coronavirus: America in chaos, News and Updates. One million Americans dead and counting (8 Viewers)

[EL PRESIDENTE]

 

[illmatic99]

got my booster this evening.

pfizer after jnj in the spring. sore arm and slight fever for now-- nothing notable. hopefully, this is it cuz the jnj hit me like a ton of bricks.

 

[barfo]

Is that a good combo @barfo?

You really can't go wrong with bbq sauce.

barfo

 

[Lanny]

Okay then the next county over.
Point being metro areas are typically blue and metro areas are where the protestors are causing “problems”

That's also where the highest crime rates are. Do you know why? Because high density areas have their criminals plus the ones from low density areas where there are fewer jobs and less money. If low density areas were to keep their problematic residents at home you'd have a lot less trouble in those big cities you refer to. By the way, Molalla has a far worse drug problem than Portland.

 

[Lanny]

must be from a right wing extreme conspiracy site though right?

oh wait. Msn? Arent they fairly liberal and left leaning?

hmmm…

What site are you referring to?

 

[Lanny]

You forgot: Americans with PhDs are most reluctant to get vaccinated against COVID

"Researchers concluded that the most educated people in our society are not only the most hesitant about getting vaccinated but are also the least likely to change their minds about it."

I call bullshit. Do you have a credible link supporting that bullshit?

 

[Orion Bailey]

At the end of the day there are several reliable and reasonable sources for this information. I don’t think many in here are going to some extreme left source and copying and pasting nonsense. We leave that for Maris. Also, we (Americans) have been absolutely bombarded with Trump and his cronies forcing the “fake news” agenda for 5 years so now every single thing is apparently a lie. The fbi, the cdc, all of it, just a big lie. It’s exhausting. We have a huge % who still read Facebook conspiracies and believe them over legitimate institutions. Is everything always perfect, no. But the govt isn’t out to get everyone and lying about every single thing. It’s out of control to the point that it is fundamentally ruining the country and dividing it like never before. It’s flat out dangerous and infuriating.

i agree. It is infuriating. But the masters behind the curtain don't change. Just the faces of politicians they buy. Big corp runs both parties and the news outlets.
Thats why i stick to my ideals regardless of party and dont trust most politically pushed news.

 

[crandc]

How can someone say they don't trust politically pushed news when they spout it over and over? CDC, NIH not perfect but they are not politically pushed news.

 

[Orion Bailey]

How can someone say they don't trust politically pushed news when they spout it over and over? CDC, NIH not perfect but they are not politically pushed news.

Anything funded will be funded by people with agendas….
No one said the cdc was politically pushed news. But the cdc is funded by some with special interests. and that brings skepticism to what is rolled out and accurate news and stats.

Coming from four years of fake news by trump that so many bitch about, i would think there would be some understanding for others who have the same concern now.

https://www.ashclinicalnews.org/online-exclusives/cdc-pressed-acknowledge-industry-funding/

 

[Orion Bailey]

That's fine. I'm not taking anything personally, and likewise, I have no ill will towards you.



I did not ever 'admit I don't converse openly and honestly'. I simply said that I address points i find interesting to discuss. Those points may not be the things you think are important, but guess what? We are different people, we are allowed to have different interests.

barfo

okay. That's such a cop out man. Only discuss what interests you..

So anything that might prove a statement you make incorrect may not interest you so you wont discuss it, which is exactly what happened initially.
You refused to address something that was showing inaccuracies in your post because it didn't “interest” you.

such a cop out…

and why i dont take anything you and some others’ posts seriously. Been this way for years.

an honest discussion involves discussing things that may not be of interest, bUt still relevant to the topic of discussion. You pick and choose and dismiss based on your interests, nOt based on the conversation at hand. So your conversing isn't honest aNd real.


i wont comment on anything that doesn't interest me. Well most people aren't interested in being wrong. So nice way of just dismissing all errors on your part. Because they aren't….interesting….

What a bs excuse…

 

[Lanny]

okay. That's such a cop out man. Only discuss what interests you..

So anything that might prove a statement you make incorrect may not interest you so you wont discuss it, which is exactly what happened initially.
You refused to address something that was showing inaccuracies in your post because it didn't “interest” you.

such a cop out…

and why i dont take anything you and some others’ posts seriously. Been this way for years.

an honest discussion involves discussing things that may not be of interest, bUt still relevant to the topic of discussion. You pick and choose and dismiss based on your interests, nOt based on the conversation at hand. So your conversing isn't honest aNd real.


i wont comment on anything that doesn't interest me. Well most people aren't interested in being wrong. So nice way of just dismissing all errors on your part. Because they aren't….interesting….

What a bs excuse…

Here's the secret, Orion Bailey, present your issues of importance such that they are more likely to be interesting to the reader.
Which reminds me, not that this pertains to you but to make it interesting to the readers in here, the number one complaint of writers about those of us who do not right professionally is the use of white space and that is to say the parsimonious use of white space.
Pardon the use of esoteric words but I strongly believe that people should constantly be using their dictionary to expand their lexicon (vocabulary). The best way to expand a vocabulary is to hear or see it in a conversation and immediately look it up.
I don't say all this for anyone in particular but just any reader interested in learning in general.

 

[barfo]

okay. That's such a cop out man. Only discuss what interests you..

So anything that might prove a statement you make incorrect may not interest you so you wont discuss it, which is exactly what happened initially.
You refused to address something that was showing inaccuracies in your post because it didn't “interest” you.

I don't think that's accurate, but feel free to post a link and prove me wrong.

barfo

 

[Phatguysrule]

Anything funded will be funded by people with agendas….
No one said the cdc was politically pushed news. But the cdc is funded by some with special interests. and that brings skepticism to what is rolled out and accurate news and stats.

Coming from four years of fake news by trump that so many bitch about, i would think there would be some understanding for others who have the same concern now.

https://www.ashclinicalnews.org/online-exclusives/cdc-pressed-acknowledge-industry-funding/

4 years of fake news doesn't make all data useless. That's what Trump's tribe would want you to think.

When official and professional experts all verify the numbers are accurate, and the numbers are generally repeatable across many different places, that means they can be trusted as a good source of information.

The way you catch fake news is by checking it against other legitimate sources.

 

[Orion Bailey]

I don't think that's accurate, but feel free to post a link and prove me wrong.

barfo

if you dont think its accurate, prove it wrong.
Dude, several here have acknowledged to me privately that you just play games here…

The proof is in half of your posts.

Self awareness is a valuable asset.

“Post a link proving i play games”…

okay. Lol…

what you believe is not a concern to me. Im not the one constantly quoting your posts put of the blue trying to call you out. Its you and your quoting my posts i respond to. I told you before if i could put you on ignore i would. The spin and games is over the top man.

Admit taking part in something just once…

just once…

but that wont interest you… so…you wont. Instead you will say prove it.

Childrens games…

Moving on now…

 

[barfo]

if you dont think its accurate, prove it wrong.
Dude, several here have acknowledged to me privately that you just play games here…

Well, that sounds like an important validation of your viewpoint. No doubt you feel good about that?

The proof is in half of your posts.

Then it should be easy for you to show an example of me refusing to continue a discussion when I've been proven wrong.

Self awareness is a valuable asset.

It's like rain, on your wedding day...

“Post a link proving i play games”…

okay. Lol…

what you believe is not a concern to me. Im not the one constantly quoting your posts put of the blue trying to call you out. Its you and your quoting my posts i respond to. I told you before if i could put you on ignore i would. The spin and games is over the top man.

Admit taking part in something just once…

just once…

but that wont interest you… so…you wont. Instead you will say prove it.

Childrens games…

Moving on now…

Cool. Let me know if you need help loading the truck.

barfo

 

[Orion Bailey]

Well, that sounds like an important validation of your viewpoint. No doubt you feel good about that?



Then it should be easy for you to show an example of me refusing to continue a discussion when I've been proven wrong.



It's like rain, on your wedding day...



Cool. Let me know if you need help loading the truck.

barfo

Yep!
That’s right!

 

[SlyPokerDog]

U of T researchers create mirror-image peptides that can neutralize SARS-CoV-2
Researchers at the University of Toronto have created chemical compounds that can neutralize SARS-CoV-2 and several of its variants.

In a recent paper published in the Journal of Medicinal Chemistry, the researchers report the creation of D-peptides that neutralize the virus and stop infection of cultured human cells.

Known as mirror-image peptides, the compounds have chemical properties that make them suitable for the development of low-cost antiviral therapeutics.

“A big advantage of mirror-image peptides is their long stability and that they are relatively cheap to produce,” says Philip Kim, senior author of the study and a professor of molecular genetics and computer science at the Donnelly Centre for Cellular and Biomolecular Research at U of T’s Temerty Faculty of Medicine.

“You could imagine them being formulated as a nasal spray to take prophylactically to prevent infection from occurring.”

Peptides are similar to proteins in that they are composed of the same amino-acids building blocks. But they are smaller than protein molecules. They can be designed to bind virtually any molecular target and with a greater specificity than small-molecule drugs, reducing the risk of side effects. In this way, peptides are similar to antibodies but are at least 100 times cheaper to produce thanks to their small size. The combination of low cost and easy scaling of manufacturing makes peptides attractive, particularly for low-income countries.

But there’s a caveat. In the body, peptides are rapidly degraded by the enzymes that have evolved to stamp out harmful versions produced by bacteria and other pathogens. But science has found a solution in mirror-image peptides that are resistant to degradation.

For reasons that remain unclear, all naturally occurring amino acids exist in a left-handed configuration, as defined by the direction in which they rotate. Consequently, all proteins and peptides are also left-handed – and known as L-peptides.


An illustration of L-peptides made from naturally occurring amino acids on the left, and their synthetic mirror-image counterparts on the right (illustration courtesy of Pedro Valiente)

A few years ago, Kim’s team developed a computational tool for the design of so-called D-peptides that have inverse geometry. These mirror-image molecules are manufactured from synthetic D-amino acids strung together in the same way as their left-handed counterparts. Using Kim’s design method, they can be engineered to bind the same targets with undiminished specificity. The main difference is that their unusual geometry makes them resistant to enzymes in the bloodstream that break down normal L-peptides.

The prospect of working with D-peptides is what enticed post-doctoral researcher Pedro Valiente to join Kim’s lab one year prior to the pandemic. When COVID-19 struck, he quickly realized they could apply their tool to try to make antivirals for COVID-19. By May 2020, Valiente had already created the compounds that would prove to be potent inhibitors of the virus, although it took another year to verify that they work as expected in human cells.

Valiente designed several D-peptides that mimic the region of the virus spike that binds the ACE2 receptor on the surface of cells. He reasoned that the peptides will bind to the receptor before the virus makes contact with it – thereby preventing infection. The hypothesis was later confirmed by the experiments with cultured human cells that were carried out by collaborators at two high-security labs in South Korea.

What’s more, the peptides worked just as well against several variants: Alpha, Beta and Gamma, which wreaked havoc over the past year after first appearing in the UK, South Africa and Brazil, respectively. Although the researchers did not investigate the Delta variant, other evidence suggests that it, too, would be susceptible to the peptide drugs, Kim says.

“While we focused on the variants that were circulating at the time when we were doing this work, the peptides should work on Delta as well based on the similarity with its receptor binding domain,” he says.

Valiente says the experience of working in Kim’s lab was especially gratifying as he was able to create a potential therapeutic at record speed during the first lockdown when most of the world was at a standstill.

By the time the researchers published their findings however, several treatments had become available, including antiviral medications, antibody cocktails and vaccines. Prompted by these global advances, the team has shifted focus from COVID-19 to trying to create compounds that target all coronaviruses, including SARS and MERS, in a bid to design a universal therapeutics as a safeguard against future pandemics.

To this end, Kim has partnered up with a Boston biotech company Decoy Therapeutics to commercialize his research.

https://www.utoronto.ca/news/u-t-researchers-create-mirror-image-peptides-can-neutralize-sars-cov-2

 

[Phatguysrule]

U of T researchers create mirror-image peptides that can neutralize SARS-CoV-2
Researchers at the University of Toronto have created chemical compounds that can neutralize SARS-CoV-2 and several of its variants.

In a recent paper published in the Journal of Medicinal Chemistry, the researchers report the creation of D-peptides that neutralize the virus and stop infection of cultured human cells.

Known as mirror-image peptides, the compounds have chemical properties that make them suitable for the development of low-cost antiviral therapeutics.

“A big advantage of mirror-image peptides is their long stability and that they are relatively cheap to produce,” says Philip Kim, senior author of the study and a professor of molecular genetics and computer science at the Donnelly Centre for Cellular and Biomolecular Research at U of T’s Temerty Faculty of Medicine.

“You could imagine them being formulated as a nasal spray to take prophylactically to prevent infection from occurring.”

Peptides are similar to proteins in that they are composed of the same amino-acids building blocks. But they are smaller than protein molecules. They can be designed to bind virtually any molecular target and with a greater specificity than small-molecule drugs, reducing the risk of side effects. In this way, peptides are similar to antibodies but are at least 100 times cheaper to produce thanks to their small size. The combination of low cost and easy scaling of manufacturing makes peptides attractive, particularly for low-income countries.

But there’s a caveat. In the body, peptides are rapidly degraded by the enzymes that have evolved to stamp out harmful versions produced by bacteria and other pathogens. But science has found a solution in mirror-image peptides that are resistant to degradation.

For reasons that remain unclear, all naturally occurring amino acids exist in a left-handed configuration, as defined by the direction in which they rotate. Consequently, all proteins and peptides are also left-handed – and known as L-peptides.


An illustration of L-peptides made from naturally occurring amino acids on the left, and their synthetic mirror-image counterparts on the right (illustration courtesy of Pedro Valiente)

A few years ago, Kim’s team developed a computational tool for the design of so-called D-peptides that have inverse geometry. These mirror-image molecules are manufactured from synthetic D-amino acids strung together in the same way as their left-handed counterparts. Using Kim’s design method, they can be engineered to bind the same targets with undiminished specificity. The main difference is that their unusual geometry makes them resistant to enzymes in the bloodstream that break down normal L-peptides.

The prospect of working with D-peptides is what enticed post-doctoral researcher Pedro Valiente to join Kim’s lab one year prior to the pandemic. When COVID-19 struck, he quickly realized they could apply their tool to try to make antivirals for COVID-19. By May 2020, Valiente had already created the compounds that would prove to be potent inhibitors of the virus, although it took another year to verify that they work as expected in human cells.

Valiente designed several D-peptides that mimic the region of the virus spike that binds the ACE2 receptor on the surface of cells. He reasoned that the peptides will bind to the receptor before the virus makes contact with it – thereby preventing infection. The hypothesis was later confirmed by the experiments with cultured human cells that were carried out by collaborators at two high-security labs in South Korea.

What’s more, the peptides worked just as well against several variants: Alpha, Beta and Gamma, which wreaked havoc over the past year after first appearing in the UK, South Africa and Brazil, respectively. Although the researchers did not investigate the Delta variant, other evidence suggests that it, too, would be susceptible to the peptide drugs, Kim says.

“While we focused on the variants that were circulating at the time when we were doing this work, the peptides should work on Delta as well based on the similarity with its receptor binding domain,” he says.

Valiente says the experience of working in Kim’s lab was especially gratifying as he was able to create a potential therapeutic at record speed during the first lockdown when most of the world was at a standstill.

By the time the researchers published their findings however, several treatments had become available, including antiviral medications, antibody cocktails and vaccines. Prompted by these global advances, the team has shifted focus from COVID-19 to trying to create compounds that target all coronaviruses, including SARS and MERS, in a bid to design a universal therapeutics as a safeguard against future pandemics.

To this end, Kim has partnered up with a Boston biotech company Decoy Therapeutics to commercialize his research.

https://www.utoronto.ca/news/u-t-researchers-create-mirror-image-peptides-can-neutralize-sars-cov-2

Exciting stuff! Though does this mean you'd need to constantly use a nasal spray to prevent infection? How long does a spray last? Or did I miss it?

 

[SlyPokerDog]

Exciting stuff! Though does this mean you'd need to constantly use a nasal spray to prevent infection? How long does a spray last? Or did I miss it?

DO YOUR OWN RESEARCH SHEEPLE!

 

[Orion Bailey]

Anything funded will be funded by people with agendas….
No one said the cdc was politically pushed news. But the cdc is funded by some with special interests. and that brings skepticism to what is rolled out and accurate news and stats.

Coming from four years of fake news by trump that so many bitch about, i would think there would be some understanding for others who have the same concern now.

https://www.ashclinicalnews.org/online-exclusives/cdc-pressed-acknowledge-industry-funding/

and silence… lol. Typical

 

[crandc]

700,000 Americans are permanently silenced. I am not laughing.

 

[Orion Bailey]

Just avoiding anything that doesn't fit ones stance.. while trying to accuse others of the same.
Thats the funny.

 

[barfo]

Here is what your link says:

"During fiscal years 2014 through 2018, the CDC Foundation received $79.6 million from companies like Pfizer, Biogen, and Merck."

So about $13M per year on average. Sounds like a lot of money, right?
But the budget for CDC in 2016 was $11.5B. In other words, the corporate funding was roughly 1/1000th of the overall budget.

If you investigate further, you'll see that the CDC Foundation money does not go into the general CDC funding pot, but rather is used for specific collaborations with the industry partner. A list of the programs is provided. None of them are 'Help Bill Gates put MICROCHIPS in the vaccines and take away FREEDUMB'.

barfo

 

[Orion Bailey]

Here is what your link says:

"During fiscal years 2014 through 2018, the CDC Foundation received $79.6 million from companies like Pfizer, Biogen, and Merck."

So about $13M per year on average. Sounds like a lot of money, right?
But the budget for CDC in 2016 was $11.5B. In other words, the corporate funding was roughly 1/1000th of the overall budget.

If you investigate further, you'll see that the CDC Foundation money does not go into the general CDC funding pot, but rather is used for specific collaborations with the industry partner. A list of the programs is provided. None of them are 'Help Bill Gates put MICROCHIPS in the vaccines and take away FREEDUMB'.

barfo

no one said anything about chips or freedumb. Only aBout special interest agendas for profit. But i wouldnt expect you to stick with the foundation of the post.
More typical spin…

oh not spin. Just commenting on what “interested you” … lol.

Yes! Thats right!

 

[barfo]

no one said anything about chips or freedumb. Only aBout special interest agendas for profit. But i wouldnt expect you to stick with the foundation of the post.
More typical spin…

I addressed that issue - only after you complained that no one was responding to you.

Maybe you didn't understand it? Here it is again.

1. Corporate funding is a tiny, tiny fraction of the CDC budget. They are not bought-and-paid-for by industry.
2. What funding they do get from industry is for specific projects, not for their general operations.

barfo

 

[Orion Bailey]

I addressed that issue - only after you complained that no one was responding to you.

Maybe you didn't understand it? Here it is again.

1. Corporate funding is a tiny, tiny fraction of the CDC budget. They are not bought-and-paid-for by industry.
2. What funding they do get from industry is for specific projects, not for their general operations.

barfo

But… Im commenting on what interests me. Sorry if that doesn't meet your satisfaction!

Yes!
Thats right!

 

[barfo]

But… Im commenting on what interests me. Sorry if that doesn't meet your satisfaction!

Yes!
Thats right!

I'm satisfied. I made the point I wanted to. And you think you made a point, so we are both happy now, right?

barfo

 

[Orion Bailey]

I'm satisfied. I made the point I wanted to. And you think you made a point, so we are both happy now, right?

barfo

oh i made my point with a thump. Right above is what you have done for a few years now. I don't expect you to get the point though…

so…

yes! Thats right!

now. Lets go get ready for the game…

 

[noknobs]

Maybe you didn't understand it? Here it is again

You might as well try to push water up a hill. But I appreciate your effort.

 

[crandc]

You might as well try to push water up a hill. But I appreciate your effort.

Something in Greek mythology about someone whose punishment in the afterlife was trying to carry water in a sieve. Can't remember who or why.