My response would be that it never precludes me from praying and having hope that God might answer my prayers in the way that "I" want Him to. God may, or may not, do that. God is God, and I'm not. Kind of like when King David fasted and prayed for over a week that his son would be healed. All of David's friends, family, and associates stood by and watched while he was going though all of this. Then, one morning David woke up and was told that his son had died. He shaved, had breakfast, then moved on with his day. Those around him were in dismay that he responded in such a manner. Essentially, David told them that God had answered in the way that He answered, and that was it. He wasn't going to question God's sovereignty in the matter. That's the dilemma many people have - Christians, and non Christians, alike: Why does God sometimes answer prayers to our benefit, and sometimes not? We'll never know this side of heaven. Faith can be a difficult thing sometimes. The bottom line is, either I believe in God, and His sovereignty/omniscience, or I don't. I choose to believe in Him, even when I don't understand why. Again, God is God, and I'm not. Simple as that.