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https://www.dailywire.com/news/univ...ook&utm_medium=social&utm_campaign=benshapiro

University: Research Team Developed ‘Breakthrough Technology’ That Could Block Coronavirus From Infecting Human Cells
James BarrettApril 23rd, 2020
GettyImages-1208729922.jpg

Olivier Douliery/AFP via Getty Images



00:13

A team of researchers at the University of Louisville say they have developed a technology that could prevent the COVID-19 virus from infecting human cells by blocking its ability to replicate itself inside the body.


The researchers’ findings were reported Wednesday by the University of Louisville’s UofL News’ Baylee Pulliam, who covers research and innovation at the university. The “breakthrough technology,” writes Pulliam, “is believed to block the novel coronavirus SARS-CoV-2 from infecting human cells.”

“The technology is based on a piece of synthetic DNA – an ‘aptamer’ – which targets and binds with a human protein called nucleolin,” Pulliam explains. “Early tests show that this aptamer may stop viruses, including novel coronavirus, from ‘hijacking’ nucleolin to replicate inside the body.”

Because of the promising results of their early testing, the university is seeking to “fast-track development, including application to the Food and Drug Administration for approval to start treating patients seriously affected with COVID-19,” Pulliam writes.

The University of Louisville’s Paula Bates, John Trent and Don Miller, have applied the aptamer in multiple ways, Pulliam explains, including as a potential therapeutic drug for some types of cancer.

In response to the coronavirus pandemic, Bates, a professor of medicine, partnered with Kenneth Palmer, director of the university’s Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases (CPM), to see how the synthetic DNA would impact SARS-CoV-2, the virus that causes COVID-19.

(more info if you click the link)
 
magnifier661 said:
https://www.dailywire.com/news/univ...ook&utm_medium=social&utm_campaign=benshapiro

University: Research Team Developed ‘Breakthrough Technology’ That Could Block Coronavirus From Infecting Human Cells
James BarrettApril 23rd, 2020
GettyImages-1208729922.jpg

Olivier Douliery/AFP via Getty Images



00:13

A team of researchers at the University of Louisville say they have developed a technology that could prevent the COVID-19 virus from infecting human cells by blocking its ability to replicate itself inside the body.


The researchers’ findings were reported Wednesday by the University of Louisville’s UofL News’ Baylee Pulliam, who covers research and innovation at the university. The “breakthrough technology,” writes Pulliam, “is believed to block the novel coronavirus SARS-CoV-2 from infecting human cells.”

“The technology is based on a piece of synthetic DNA – an ‘aptamer’ – which targets and binds with a human protein called nucleolin,” Pulliam explains. “Early tests show that this aptamer may stop viruses, including novel coronavirus, from ‘hijacking’ nucleolin to replicate inside the body.”

Because of the promising results of their early testing, the university is seeking to “fast-track development, including application to the Food and Drug Administration for approval to start treating patients seriously affected with COVID-19,” Pulliam writes.

The University of Louisville’s Paula Bates, John Trent and Don Miller, have applied the aptamer in multiple ways, Pulliam explains, including as a potential therapeutic drug for some types of cancer.

In response to the coronavirus pandemic, Bates, a professor of medicine, partnered with Kenneth Palmer, director of the university’s Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases (CPM), to see how the synthetic DNA would impact SARS-CoV-2, the virus that causes COVID-19.

(more info if you click the link)
Click to expand...

that's interesting, although pretty short on details (not that I'd understand it if there were more details)

one thing I'm thinking is that even if there is a lot of trouble coming up with treatments for Covid, the worldwide focus on the science and medicine needed to combat this pandemic will almost certainly advance medicine in many other ways. For instance, the massive investment in the space program in the 60's & 70's spun off a wide array of new technologies....I think this pandemic might fuel a similar situation. Silver linings
 
wizenheimer said:
that's interesting, although pretty short on details (not that I'd understand it if there were more details)

one thing I'm thinking is that even if there is a lot of trouble coming up with treatments for Covid, the worldwide focus on the science and medicine needed to combat this pandemic will almost certainly advance medicine in many other ways. For instance, the massive investment in the space program in the 60's & 70's spun off a wide array of new technologies....I think this pandemic might fuel a similar situation. Silver linings
Click to expand...
Did you click the link? There was much more in the article. I think there were links to studies as well.
 
magnifier661 said:
You’re probably right. The great thing for me was seeing these cool new studies on possible Covid-19 treatments. Interesting reads! :)
Click to expand...
But his audience only knows vernacular.
Also, his use of the terms light and bleach lead most people down a different path than you envisage.
 
New York hospitals are quietly testing a HEARTBURN drug as treatment for COVID-19 and will know whether it's effective in 'a few weeks'
  • Doctors in China discovered that in people over 80 there was a higher COVID-19 survival rate in patients who were poor
  • Those over 80 with heartburn issues and that used the cheaper drug, Pepcid, had a higher survival rate than those using the expensive alternative, Prilosec
  • Pepcid contains famotidine and Prilosec contains omeprazole
  • Scientists suspect that in COVID-19, famotidine binds to the papainlike protease which helps pathogens replicate in the body and stops them replicating
  • Northwell Health has been injecting patients in New York with famotidine
  • Interim results from 391 patients should be available in 'a few weeks' Kevin Tracey, a former neurosurgeon in charge of Northwell's research said
https://www.dailymail.co.uk/news/ar...rug-famotidine-Pepcid-treatment-COVID-19.html
 
SlyPokerDog said:
New York hospitals are quietly testing a HEARTBURN drug as treatment for COVID-19 and will know whether it's effective in 'a few weeks'
  • Doctors in China discovered that in people over 80 there was a higher COVID-19 survival rate in patients who were poor
  • Those over 80 with heartburn issues and that used the cheaper drug, Pepcid, had a higher survival rate than those using the expensive alternative, Prilosec
  • Pepcid contains famotidine and Prilosec contains omeprazole
  • Scientists suspect that in COVID-19, famotidine binds to the papainlike protease which helps pathogens replicate in the body and stops them replicating
  • Northwell Health has been injecting patients in New York with famotidine
  • Interim results from 391 patients should be available in 'a few weeks' Kevin Tracey, a former neurosurgeon in charge of Northwell's research said
https://www.dailymail.co.uk/news/ar...rug-famotidine-Pepcid-treatment-COVID-19.html
Click to expand...

great...now people will start hoarding Tums
 
US doctors have started giving men with coronavirus ESTROGEN in the hopes of boosting their immune systems after finding the virus kills half as many women
  • Around the world, higher rates of men have been coming down with severe cases of the coronavirus and dying compared to women
  • Some researchers believe it's due to the female sex hormones mainly produced by women, estrogen and progesterone
  • Stony Brook University in New York and Cedars-Sinai in California will each be giving male coronavirus patients one of the two hormones
  • They will see if the hormones boost the male patients' immune systems, decreases inflammation and reduces the severity of the illness
https://www.dailymail.co.uk/health/...VID-Female-hormones-prevent-inflammation.html
 
SlyPokerDog said:
US doctors have started giving men with coronavirus ESTROGEN in the hopes of boosting their immune systems after finding the virus kills half as many women
  • Around the world, higher rates of men have been coming down with severe cases of the coronavirus and dying compared to women
  • Some researchers believe it's due to the female sex hormones mainly produced by women, estrogen and progesterone
  • Stony Brook University in New York and Cedars-Sinai in California will each be giving male coronavirus patients one of the two hormones
  • They will see if the hormones boost the male patients' immune systems, decreases inflammation and reduces the severity of the illness
https://www.dailymail.co.uk/health/...VID-Female-hormones-prevent-inflammation.html
Click to expand...

oh shit

if I get covid, they jack me full of estrogen, I survive, and then want to watch Jane Austen movies, I'll shoot myself.....better.....off.....dead
 
SlyPokerDog said:
US doctors have started giving men with coronavirus ESTROGEN in the hopes of boosting their immune systems after finding the virus kills half as many women
  • Around the world, higher rates of men have been coming down with severe cases of the coronavirus and dying compared to women
  • Some researchers believe it's due to the female sex hormones mainly produced by women, estrogen and progesterone
  • Stony Brook University in New York and Cedars-Sinai in California will each be giving male coronavirus patients one of the two hormones
  • They will see if the hormones boost the male patients' immune systems, decreases inflammation and reduces the severity of the illness
https://www.dailymail.co.uk/health/...VID-Female-hormones-prevent-inflammation.html
Click to expand...
Hey, I once took that stuff but I began having these nasty dreams about me and Sly. I puked all over the place and on the poster of Sly hanging over my bed. This caused me to immediately call my doctor and told him we had to try something else. Shudder.
 
https://apple.news/APrSVHgDmQ0OG8ITf8Th-hw

Stocks extend surge, with Dow rallying 600 points to session high

Stocks jumped Wednesday on the back of positive data from a potential coronavirus treatment from Gilead Sciences, while investors digested a sharp drop in U.S. economic activity.

The Dow Jones Industrial Average surged 605 points, or 2.5%. The S&P 500 gained 2.9% while the Nasdaq Composite traded 3.5% higher.

Wednesday's gains put the S&P 500 up more than 14% for the month. That would be the index's biggest one-month gain since 1974. The Dow is up 12.8% for April and is headed for its biggest monthly gain since 1987.

A study of Gilead's remdesivir drug conducted by the National Institute of Allergy and Infectious Diseases met its primary endpoint, the drugmaker said, lifting expectations for a potential coronavirus treatment. Gilead also released the results of its own study, which showed improvement in patients taking remdesivir to treat the virus. Gilead shares jumped 9.4% after a brief halt in the premarket.

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said remdesivir shows a "clear-cut" positive effect when treating the virus.

"Markets are going to move like this on this kind of news," said Megan Horneman, director of portfolio strategy at Verdence Capital Advisors. "If we had a vaccination, then I think you would see a very different economic recovery. If we have treatments, I think you'll see a little bit quicker of an economic recovery."

"We'll take these days, but we're not investing or changing any of our asset allocation because one day," Horneman said.

Sentiment was also lifted as Alphabet shares gained 8.7% after the tech giant reported a revenue growth decline that was less steep than forecast. The company's YouTube ad revenues also beat expectations.

Other mega-cap tech stocks such as Facebook climbed 6.5%. Amazon gained 2.1% while Apple advanced 3.3%.

The Gilead news along with the strong move higher from Alphabet offset news of a steep drop in U.S. economic activity. U.S. GDP shrank by 4.8% in the first quarter for the country's biggest contraction since the financial crisis.
 
I guess a test with a sample size of 60k is a nothing burger. Maybe we need to share a test of 20 people dying holds more weight?
 
magnifier661 said:
I guess a test with a sample size of 60k is a nothing burger. Maybe we need to share a test of 20 people dying holds more weight?
Click to expand...

Your link is most certainly a nothing burger.

It natters on about other topics - something about a student and his theory of the MoA of the coronvirus - and then the last paragraph finally mentions what you suggest:

google translate said:
Finally, further confirmation of this hypothesis is the data collected in the register of the SIR (Italian rheumatology society). To assess the possible correlations between chronic patients and Covid19, SIR interrogated 1,200 rheumatologists throughout Italy to collect statistics on infections. Out of an audience of 65,000 chronic patients (Lupus and Rheumatoid Arthritis), who systematically take Plaquenil / hydroxychloroquine, only 20 patients tested positive for the virus. Nobody died, nobody is in intensive care, according to the data collected so far.
Click to expand...

So several questions: is there an actual publication on this? Did they actually get information on 65,000 patients, or only on some of them "so far"? If not all, how many? Did they actually test anyone, or was this just asking rheumatologists to report if they know of any covid-positives among their hydroxychloroquine users? How many of the 1200 docs actually responded?

barfo
 
barfo said:
Your link is most certainly a nothing burger.

It natters on about other topics - something about a student and his theory of the MoA of the coronvirus - and then the last paragraph finally mentions what you suggest:



So several questions: is there an actual publication on this? Did they actually get information on 65,000 patients, or only on some of them "so far"? If not all, how many? Did they actually test anyone, or was this just asking rheumatologists to report if they know of any covid-positives among their hydroxychloroquine users? How many of the 1200 docs actually responded?

barfo
Click to expand...
It’s a study on those already taking the medication and their infection rate. 65k is more than a nothing burger.

mags
 
magnifier661 said:
It’s a study on those already taking the medication and their infection rate. 65k is more than a nothing burger.

mags
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Based on what you posted, it's not necessarily a study, and it's not necessarily on 65k people. You need a better link.

barfo
 
barfo said:
Based on what you posted, it's not necessarily a study, and it's not necessarily on 65k people. You need a better link.

barfo
Click to expand...
Here is the english translation of the article:

Annalisa Chiusolo, a young pharmacology scholar, sensed the mechanism of action of Sars-Cov-2. By understanding this mechanism, the most effective contrast drugs can be accurately and precisely targeted and selected. Coronavirus would affect the ability of hemoglobin to transport oxygen, creating the underlying assumptions of the impulsive lung complications, unfortunately known: breathlessness, dyspnoea, up to severe acute respiratory syndrome and death.

Theory is the first step in any verification. Science proceeds by refutations. If this thesis were confirmed, many unknowns would be explained, for example why Covid-19 affects more men, diabetics, and less women in general, and even less pregnant women, and very few children and thalassemia. The circle would close.

But let's get into the merits of the theory. The virus needs porphyrins for its survival, probably for its replication, therefore it attacks hemogloblin (the protein that carries oxygen in the blood), in particular the OFR10 and OFR3 proteins attack the beta chain and orf1ab subtracts porphyrin. The concepts seem a little abstruse, for a non-expert, but simplifying this translates into a lower availability of oxygen available to our body, with consequent accumulation of carbon dioxide. So the lung cells become distressed and become the site of the cytokine cascade - that is, a huge immune response - responsible for the acute inflammation that characterizes Covid-19 pneumonia. The hemoglobin value in the blood can be an important parameter for evaluating Sars-Cov2 infection: in men the normal value of Hb (hemoglobin) is higher than in women, which would explain the higher incidence of Covid pneumonia in men than to women, the lower incidence and the better prognosis in children and pregnant women, where the Hb values are lower due to an increased need for iron, which makes the "nourishment" of the virus less available. In elderly or middle-aged patients with diabetes, Covid pneumonia19 has a higher incidence, therefore linked to the increase in blood glucose Hb, and therefore there is greater "nourishment" for the virus.

Viral damage, therefore, is systemic, that is, it affects the blood and is not confined only to the lung. This would also explain the birth of healthy babies from positive Covid mothers. Because in fetal Hb - stay seated, we will now use some technical concepts, but let's get back to it right away - the two beta chains are replaced by two gamma chains, a difference is the presence of a residue of serine, instead of a histidine present in the same position of the beta chain, probably responsible for binding to viral proteins, which could mimic the action of 2,3 bisphosphoglycerate. Now you can get up, let's go back to using more understandable language. All this would explain the lower incidence and the best course of the pathology in newborns, missing the main site of action of viral proteins, namely the beta chains of Hb, in short in newborns the same concept of "nourishment is lacking ”For the coronavirus.

The same goes for a chronic disease called Beta-Thalassemia, where the "beta" chains of hemoglobin (the target of the virus) are deficient or even absent. This would demonstrate the lower incidence and better prognosis and course of the pathology in beta thalassemia, which in Italy are widespread in Mediterranean areas such as Puglia, Sicily and Sardinia (in particular in the southern area) where there is an equal thalassemia rate at 12% (alpha and beta). To confirm this theory, there is a scientific publication that has linked subjects affected by beta thalassemia and Covid19, in the data taken from pubmed: as of April 10, 2020, 11 cases of positive Covid betatalaxemia have been recorded in Northern Italy, where the rate of contagiousness it is higher: 10 of them with transfusion-dependent thalassemia, the most severe form, only one with non-transfusion-dependent thalassemia.

All patients who contracted the virus, however, had concomitant, very serious diseases: splenectomized, pulmonary hypertension, lymphoma and chemotherapy. Despite this multi-pathological picture, no death, no cytokine storm or severe Sars was recorded in the 11 subjects.

Once the main mechanism of action of the virus has been revealed, many other things can be understood. For example, the central mechanism of action of hydroxychloroquine can now be explained and fully understood, and its effectiveness in countering Covid19. What this mechanism consists of is immediately said: the drug by binding permanently with ferriprotoporphyrin (of the Eme group of Hb) removes the substrate from viral proteins and also becomes an important means of prophylaxis. Although there are still no Italian publications on the effectiveness of hydroxychloroquine as a "shielding" from the virus, among the directors of the infectious disease wards, the specialists, Primaries and general practitioners contacted during this research, many admitted - under a whisper - to use the drug as a "prophylaxis", that is, to prevent infection. Healthcare professionals who are in close contact with contagious patients take the drug in advance, precisely to decrease the probability of contracting the infection. For now, in support of this "prophylaxis" effect, there is a recent publication, involving 211 people. It's been published International Journal of Antimicrobial Agents
Finally, further confirmation of this hypothesis is the data collected in the register of the SIR (Italian rheumatology society). To assess the possible correlations between chronic patients and Covid19, SIR interrogated 1,200 rheumatologists throughout Italy to collect statistics on infections. Out of an audience of 65,000 chronic patients (Lupus and Rheumatoid Arthritis), who systematically take Plaquenil / hydroxychloroquine, only 20 patients tested positive for the virus. Nobody died, nobody is in intensive care, according to the data collected so far.
 
Here is a smaller study they were also referencing @barfo

https://www.sciencedirect.com/science/article/pii/S092485792030145X?via=ihub

5. Conclusion
In this study, PEP with HCQ was implemented safely under proper monitoring and no additional patients were diagnosed with COVID-19. Randomized clinical studies are needed to evaluate whether PEP is an effective option for an outbreak response strategy against COVID-19 in LTCHs.
 
magnifier661 said:
Here is the english translation of the article:

Finally, further confirmation of this hypothesis is the data collected in the register of the SIR (Italian rheumatology society). To assess the possible correlations between chronic patients and Covid19, SIR interrogated 1,200 rheumatologists throughout Italy to collect statistics on infections. Out of an audience of 65,000 chronic patients (Lupus and Rheumatoid Arthritis), who systematically take Plaquenil / hydroxychloroquine, only 20 patients tested positive for the virus. Nobody died, nobody is in intensive care, according to the data collected so far.
Click to expand...

Yeah, I already posted this part, which is the only relevant part. And also pointed out that there's no detail here, no link to an actual study, etc. So, find me the study, and I'll take it seriously.

Otherwise, you might as well just repost a video of Trump saying 'what do you have to lose' and 'try it' in that creepy drug dealer voice.

barfo
 
barfo said:
Thanks. As I read it, it doesn't seem like there was a control group, although they do say that the HCQ patients had a lower mortality than others?
The results seem ok but how they compare to other/no treatments isn't clear.

barfo
Click to expand...
I’m not sure there was a control group. It was just reported that it was finally peer reviewed.
 
Malaria drug touted by Trump for coronavirus fails another test
"We didn't see any association between getting this medicine and the chance of dying or being intubated," lead researcher Dr. Neil Schluger told Reuters in a telephone interview. "The patients who got the drug didn't seem to do any better."

Among patients given hydroxychloroquine, 32.3% ended up needing a ventilator or dying, compared with 14.9% of patients who were not given the drug.

But doctors were more likely to give hydroxychloroquine to sicker patients, so researchers at New York-Presbyterian Hospital and Columbia University Irving Medical Center adjusted the rates to account for that. They concluded that the drug may not have hurt patients, but it clearly did not help.

https://www.msn.com/en-us/news/us/m...or-coronavirus-fails-another-test/ar-BB13KQ4Z
 
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