I think you can have 2 non-shooters on the floor, Simmons and the Center. It would be ideal to have a Center who can hit the 3 next to Simmons of course. Obviously you have to have good shooters surrounding them. It could be a bit of a problem with Scoot still needing to find his 3-ball.
I also think that playing Simmons at center is an intriguing idea. Sure he can't stop Jokic or Embiid, but then, who can? He would be god tier for switching on the Pick and Roll at the center position and then you could easily surround him with 3-4 shooters and he becomes a secondary ballhandler on the break and a pick and roll nightmare with Scoot.